The project aims to develop new U-space advanced services together with a central command and control centre (C2C), as well as an automated ground integration (Drone Cargo Port - DCP) to facilitate automated time-critical drone-based services for medical and non-medical use cases. Specifically, research will focus on a dynamic capacity management system (U3), detect and avoid algorithms (U3) and machine to machine communication and decision making (U4). The project will extend use cases to non-medical critical missions, such as shore to ship for the transport of materials and the inspection of railway and electric grids in case of unforeseen issues with the infrastructure (e.g. tree fallen on high tension cable).